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Systemic and Diagnostic Virology-I

MB 558 | Past Questions & Question Bank

MSc Medical Microbiology - Semester II

Organized according to the official TU MB 558 syllabus. Actual university past-paper questions should be added separately when the original papers are available.

1. Techniques of Diagnostic Virology
2 Marks
  1. Define diagnostic virology.
  2. What is haemagglutination?
  3. What is haemagglutination inhibition?
  4. State the principle of complement fixation test.
  5. What is a neutralization test?
  6. What is Western blot?
  7. What is RIPA?
  8. Define nucleic-acid hybridization.
  9. What is PCR?
  10. What is nucleotide sequencing?
  11. State one application of electron microscopy in virology.
5 Marks
  1. Describe the principle and procedure of haemagglutination test.
  2. Discuss haemagglutination inhibition test.
  3. Explain the complement fixation test with its applications.
  4. Describe the neutralization test.
  5. Explain Western blot technique and its applications.
  6. Describe PCR as a diagnostic method for viral infections.
  7. Write a short note on nucleic-acid hybridization.
  8. Describe fluorescence microscopy in viral diagnosis.
10 Marks
  1. Discuss the major techniques used in diagnostic virology with suitable examples.
  2. Discuss serodiagnostic methods used for viral infections, including their principles and applications.
  3. Describe nucleic-acid based methods used in diagnosis of viral infections.
  4. Discuss PCR, microarray and nucleotide sequencing in viral diagnosis.
2. Specimen Handling
5 Marks
  1. Describe the selection and collection of specimens for viral diagnosis.
  2. Discuss transportation and processing of clinical specimens for viral diagnosis.
10 Marks
  1. Discuss selection, collection, transportation and processing of clinical specimens for laboratory diagnosis of viral infections.
3. Poxviruses
5 Marks
  1. Describe the structure of smallpox virus.
  2. Write a short note on smallpox.
  3. Discuss laboratory diagnosis of smallpox.
10 Marks
  1. Discuss smallpox virus with reference to structure, pathogenesis, clinical manifestations, laboratory diagnosis and control.
4. Herpesviruses
5 Marks
  1. Describe the structure of herpes simplex virus.
  2. Discuss latency in herpes simplex virus.
  3. Write a short note on varicella-zoster virus.
  4. Discuss congenital CMV infection.
  5. Write a short note on HHV-6.
  6. Write a short note on HHV-7.
  7. Discuss Epstein-Barr virus and infectious mononucleosis.
  8. Describe laboratory diagnosis of herpesvirus infections.
10 Marks
  1. Discuss HSV infection with reference to structure, replication, pathogenesis, clinical manifestations and laboratory diagnosis.
  2. Discuss varicella-zoster virus infection with reference to pathogenesis and laboratory diagnosis.
  3. Describe CMV infection including congenital disease, pathogenesis and laboratory diagnosis.
  4. Discuss EBV infection with special reference to infectious mononucleosis and laboratory diagnosis.
5. Picornaviruses
5 Marks
  1. Describe the general characteristics of picornaviruses.
  2. Discuss the structure and genome of picornaviruses.
  3. Describe laboratory diagnosis of picornavirus infections.
10 Marks
  1. Discuss picornaviruses with reference to structure, replication, pathogenesis, medical importance and laboratory diagnosis.
6. Orthomyxoviruses
5 Marks
  1. Describe the structure of influenza virus.
  2. Discuss antigenic drift and antigenic shift.
  3. Describe laboratory diagnosis of influenza.
10 Marks
  1. Discuss influenza virus with reference to structure, replication, antigenic variation, pathogenesis, clinical manifestations and laboratory diagnosis.
7. Paramyxoviruses
5 Marks
  1. Describe the structure of measles virus.
  2. Discuss pathogenesis of measles.
  3. Describe laboratory diagnosis of measles.
  4. Write a short note on mumps virus.
  5. Write a short note on human parainfluenza viruses.
  6. Discuss respiratory syncytial virus infection.
10 Marks
  1. Discuss measles virus with reference to pathogenesis, clinical manifestations, complications and diagnosis.
  2. Discuss mumps virus infection with reference to pathogenesis, clinical manifestations and diagnosis.
  3. Describe human respiratory syncytial virus with reference to pathogenesis, clinical disease and laboratory diagnosis.
8. Arboviruses
5 Marks
  1. Define arbovirus.
  2. Describe dengue virus.
  3. Discuss dengue pathogenesis.
  4. Describe laboratory diagnosis of dengue.
  5. Write a short note on Japanese encephalitis virus.
  6. Discuss laboratory diagnosis of Japanese encephalitis.
  7. Write a short note on yellow fever virus.
10 Marks
  1. Discuss dengue virus infection with reference to structure, pathogenesis, clinical manifestations and laboratory diagnosis.
  2. Discuss Japanese encephalitis virus with reference to transmission, pathogenesis, clinical features and laboratory diagnosis.
  3. Discuss yellow fever virus with reference to transmission, pathogenesis, clinical features, diagnosis and prevention.
9. Retroviruses
5 Marks
  1. Describe the structure of HIV.
  2. Discuss the HIV replication cycle.
  3. Describe HIV pathogenesis.
  4. Discuss laboratory diagnosis of HIV infection.
  5. Write a short note on HTLV.
10 Marks
  1. Discuss HIV infection with reference to structure, genome organization, replication, pathogenesis, clinical manifestations and laboratory diagnosis.
  2. Discuss laboratory diagnosis of HIV infection using serological and molecular methods.
  3. Describe HTLV with reference to structure, transmission, associated diseases and diagnosis.

Important

This page currently contains an organized MSc-level question bank based on the TU MB 558 syllabus. It should not be represented as a collection of verified university past-paper questions.

Once actual TU question-paper photographs/PDFs are available, they can be added under separate Year-wise Past Questions sections.